সংজ্ঞা
Islet cells are the cells in the pancreas that make insulin. Pancreatic islet cell transplantation is the transfer of islet cells from a donor to another person. The procedure is being studied as a method to treat select patients with chronic uncontrolled type 1 (and some type 2) diabetes.
পদ্ধতির কারণ
Pancreatic islet cells are made up of alpha and beta cells. টাইপ 1 ডায়াবেটিস develops when the beta cells in the pancreas are destroyed. They are destroyed by the body’s own রোগ প্রতিরোধক ব্যবস্থাপনা. Without these cells, the body is unable to make insulin. As a result, people with type 1 diabetes need daily insulin injections.
Transplants are most commonly used for persons with recurrent severe hypoglycemia (low blood sugars) and/or who are also receiving kidney transplants. Newly transplanted islet cells can produce insulin. This allow better daily control of the blood sugars with a lower risk of hypoglycemia.
সম্ভাব্য জটিলতা
If you are planning to have a transplant, your doctor will review a list of possible complications, which may include:
- Toxicity from immunosuppressive agents
- Injury to the liver or the pancreas
- Cholesterol problems
- Sensitization—The recipient may form antibodies to future islet cells for repeat transplant.
- Nausea, vomiting, and abdominal pain
- রক্তপাত
- সংক্রমণ
- রক্ত জমাট
- Worsening of kidney function
- Worsening of high blood pressure
জটিলতার ঝুঁকি বাড়াতে পারে এমন কারণগুলির মধ্যে রয়েছে:
- ধূমপান
- কিডনি রোগ
- রক্তপাতের ব্যাধি
কি আশা করছ
পদ্ধতির আগে
A review board will determine if you will be eligible for a transplant. Once on the transplant list, one may have to wait months or years for a suitable donor.
Your doctor will order blood tests. A physical exam will be done. These tests will assess the extent and severity of diabetic complications. This includes damage to the kidneys. The donor must also be carefully screened for blood and serum matching.
এনেস্থেশিয়া
Local or general anesthesia may be used. Local will numb the area. You will be asleep with general anesthesia.
পদ্ধতির বর্ণনা
Pancreas transplant surgery is major surgery and requires special expertise in select medical centers. The cells are delicate and may fail even in the best of circumstances.
Before surgery, islet cells are removed from a donor pancreas. Usually, these cells are used within the next 24 hours.
An incision will be made in the abdomen. A small plastic tube will be placed through the incision and into a major blood vessel of the liver. An ultrasound will be used to locate the right position. Islets cells will be injected through the tube. The cells travel through the vein and attach to the liver. When successful, they will begin making insulin.
অবিলম্বে প্রক্রিয়া পরে
Your blood glucoses may be normal immediately following transplantation.
Your immune system may attack the transferred cells. To prevent this type of attack, called rejection, you will be given medicines to suppress your immune system.
Similar medicines to suppress the immune system are usually needed for the rest of the person’s life to prevent rejection.
এতে কতক্ষণ সময় লাগবে?
Generally several hours
এটা কতটা আঘাত করবে?
The area of surgical incision may sting or burn. Anesthesia will prevent pain during the procedure. After the procedure, some patients experience pain or soreness for a few days. If you have discomfort, ask your doctor about pain medicine.
গড় হাসপাতালে থাকার
4-10 days
পোস্ট-প্রক্রিয়া যত্ন
- Keep the incision wound clean.
- Follow your doctor’s instructions about wound care.
- Check your blood glucose frequently. Follow your doctor’s instructions.
- Closely control blood sugar levels with insulin.
Your doctor may repeat the process several times to transfer more islet cells.
আপনার ডাক্তারকে কল করুন
আপনি হাসপাতাল ছেড়ে যাওয়ার পরে, নিম্নলিখিতগুলির মধ্যে যেকোনটি ঘটলে আপনার ডাক্তারের সাথে যোগাযোগ করুন:
- জ্বর এবং ঠাণ্ডা সহ সংক্রমণের লক্ষণ
- লালভাব, ফোলাভাব, ক্রমবর্ধমান ব্যথা, অত্যধিক রক্তপাত, বা কাটা স্থান থেকে স্রাব
- কাশি, শ্বাসকষ্ট, বুকে ব্যথা, বা তীব্র বমি বমি ভাব বা বমি
- High or low blood glucose levels
জরুরী পরিস্থিতিতে, অবিলম্বে চিকিৎসা সহায়তার জন্য কল করুন।