Definition
Adrenocortical carcinoma is cancer of the adrenal cortex. The adrenal glands are two glands located just above each kidney. The glands produce important hormones. These hormones regulate heart rate, blood pressure, and many other vital functions. The adrenal cortex is the outside layer of the two adrenal glands.
Cancers of the adrenal cortex are very rare. It occurs in 0.5-2 cases per million. The majority of these tumors produce excess hormones. The excess hormones can change hormonal balance.
Causes
The cause is unknown.
Risk Factors
There are few known risk factors for cancers of the adrenal cortex. But, the following factors may contribute:
- Sex: female
- Children under 5 years old
- Adults between 40 to 50 years old
- A genetic defect may cause adrenocortical cancer in some children, but the majority of cases are non-hereditary
Symptoms
Approximately 40% of adrenocortical carcinoma do not secrete any hormone. These people do not have any specific symptoms. Adrenocortical carcinoma is discovered either by accident or as part of a physical examination for abdominal pain.
Other tumors are hormonally active (functional). Excess hormones may produce symptoms such as:
- High blood pressure
- Weakening of the bones
- Diabetes
Other conditions that may result from functional tumors of the adrenal cortex include:
- Cushing’s syndrome (Hypercortisolism)—30% of cases—excess cortisol which helps the body respond to stressful situations and infections
- Conn’s syndrome (Hyperaldosteronism)—2% of cases—excess aldosterone, which helps the body maintain normal levels of sodium and potassium
- Virilization (20% of cases)—women with functional tumors that release males hormones; may deepen voice, cause hirsutism (growing excess hair on the face), and swelling of the sex organs or breasts may occur
- A mixed Cushing’s syndrome and virilization accounts for 35% of all cases
- In young children with functional tumors that release sex hormones, these tumors may cause early onset of puberty
These symptoms may be caused by other health conditions. Anyone experiencing these symptoms should see a doctor.
Diagnosis
Your doctor will ask about your symptoms, and medical and family history. A physical exam will be done.
Tests may include the following:
- Blood tests to look for hormones from the adrenal glands
- Urine tests (24 hour cortisol)
- Your doctor may need detailed pictures of the body. These can be made with:
- CT scan of the abdomen
- MRI of the abdomen
- PET/CT scan
- Adrenal angiography and/or venography
- X-ray
After cancer of the adrenal cortex is confirmed, you will be referred to an oncologist. This type of doctor focuses on cancer.
Additional testing will be done to determine what stage (1-4) the cancer has reached. The stage of a tumor is determined by its size and how far it has spread from its point of origin. At the time of diagnosis, 30%-85% of patients are found to have cancer that has spread. The higher the stage, the more dangerous and difficult it is to treat.
Treatment
Treatment depends on the stage of the tumor and your overall health. Talk with your doctor about the best plan for you.
The following methods are used to treat cancer of the adrenal cortex:
Adrenalectomy Surgery to Remove the Tumor
Surgery to remove the adrenal tumor is the first treatment approach for about 75 % of all cases. The doctor will also need to remove any surrounding tissues or lymph nodes that contain cancer cells.
Radiation therapy and Chemotherapy
These treatments tend to be less effective in treating this type of cancer. They are most often used if the cancer has spread. Chemotherapy may also be used if there is a high chance the cancer will come back.
Other Therapies
- Mitotane is the drug most often used for this type of cancer. It blocks hormone production by the adrenal gland. It also destroys adrenal cancer cells. This drug does have serious side effects.
- Especially helpful in treating functional tumors of the adrenal cortex
- Other hormone blocking drugs may be given if mitotane does not work.
- Research of new drug and radiation therapies are under way. This includes gene and immunotherapy. Your doctor may advise you to participate in one of these trials.
If treatment is successful, you will still need to be screened for reoccurrence of the cancer on a periodic basis.
Prevention
There are no known preventive measures. Healthy lifestyle choices may reduce your risk for cancers of all types.
Adrenocortical Carcinoma Treatment in India – Page Keywords:
Adrenocortical Carcinoma Definition, Adrenocortical Carcinoma Definition Causes, Adrenocortical Carcinoma Symptoms, Adrenocortical Carcinoma Treatment in India, Adrenocortical Carcinoma Treatment Cost in India, Adrenocortical Carcinoma Surgery Cost, Top Adrenocortical Carcinoma Treatment Hospital, Top Adrenocortical Carcinoma Treatment Doctor in India, Adrenocortical Carcinoma Meaning in Marathi, Adrenocortical Carcinoma Treatment Near me, Adrenocortical Carcinoma Complications, Travel India for Adrenocortical Carcinoma Treatment, Adrenocortical Carcinoma Treatment in Arab Countries, Adrenocortical Carcinoma Treatment in Bangladesh, Adrenocortical Carcinoma Treatment in Dhaka, Adrenocortical Carcinoma Meaning in Bengali, Adrenocortical Carcinoma Meaning in Arabic, Adrenocortical Carcinoma Meaning in Hindi, Adrenocortical Carcinoma Treatment in Bahrain, Adrenocortical Carcinoma Treatment in Egypt, Adrenocortical Carcinoma Treatment in Iraq, Adrenocortical Carcinoma Treatment in Jordan, Adrenocortical Carcinoma Treatment in Kuwait, Adrenocortical Carcinoma Treatment in Lebanon, Adrenocortical Carcinoma Treatment in Saudi Arabia, Adrenocortical Carcinoma Treatment in United Arab Emirates, Adrenocortical Carcinoma Treatment in Sudan, Adrenocortical Carcinoma Treatment in Tunisia, Adrenocortical Carcinoma Treatment in Nepal, Adrenocortical Carcinoma Treatment cost,
Adrenocortical Carcinoma Treatment Cost in India, Adrenocortical Carcinoma Top Doctors Best Hospital in India